Fig. 2

Comet plots of the top CpGs for trimesters 1, 2, and 3. The upper panel of each comet plot shows the EWAS associations with -log₁₀(p value) on the y-axis and CpG position on the x-axis; the middle panel depicts annotation tracks, including gene (yellow), GC content (red), and CpG islands (green); the lower panel shows the beta value correlation matrix between the selected CpGs. A For trimester 1, a window of length of 15,500 bp on chromosome 7 centered by the top CpG is shown. B For trimester 2, there were 15 CpGs within the window of 13,000 bp on chromosome 10 centered by the top CpG. C For trimester 3, the window of 25,000 bp on chromosome 6 centered by the top CpG shows 14 CpGs in this region